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Results for "

NRF2 activation

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (3) AMPK (1) Antibiotic (4) Apoptosis (22) ATF6 (1) ATP Synthase (1) Autophagy (22) Bacterial (4) Bcl-2 Family (2) Caspase (3) Cholinesterase (ChE) (1) COX (1) Drug Metabolite (1) EGFR (1) Endogenous Metabolite (9) ERK (4) Ferroptosis (5) Fungal (4) GABA Receptor (1) Glutathione Peroxidase (2) HDAC (1) HIF/HIF Prolyl-Hydroxylase (3) Histone Methyltransferase (1) HIV (4) IKK (4) Interleukin Related (1) Isotope-Labeled Compounds (6) JNK (3) Keap1-Nrf2 (86) Mitophagy (4) MMP (1) mTOR (2) Necroptosis (1) NF-κB (8) NO Synthase (1) Organoid (1) p38 MAPK (2) p62 (1) Parasite (1) PARP (1) Phosphatase (1) PI3K (1) PPAR (6) RAR/RXR (5) Reactive Oxygen Species (17) Ribosomal S6 Kinase (RSK) (1) SARS-CoV (2) Sirtuin (7) STAT (1) STING (1) TNF Receptor (2) Topoisomerase (1)
By Research Areas:	Cancer (49) Cardiovascular Disease (15) Endocrinology (1) Infection (7) Inflammation/Immunology (39) Metabolic Disease (14) Neurological Disease (17)

By Targets:

Akt (3)

AMPK (1)

Antibiotic (4)

Apoptosis (22)

ATF6 (1)

ATP Synthase (1)

Autophagy (22)

Bacterial (4)

Bcl-2 Family (2)

Caspase (3)

Cholinesterase (ChE) (1)

COX (1)

Drug Metabolite (1)

EGFR (1)

Endogenous Metabolite (9)

ERK (4)

Ferroptosis (5)

Fungal (4)

GABA Receptor (1)

Glutathione Peroxidase (2)

HDAC (1)

HIF/HIF Prolyl-Hydroxylase (3)

Histone Methyltransferase (1)

HIV (4)

IKK (4)

Interleukin Related (1)

Isotope-Labeled Compounds (6)

JNK (3)

Keap1-Nrf2 (86)

Mitophagy (4)

MMP (1)

mTOR (2)

Necroptosis (1)

NF-κB (8)

NO Synthase (1)

Organoid (1)

p38 MAPK (2)

p62 (1)

Parasite (1)

PARP (1)

Phosphatase (1)

PI3K (1)

PPAR (6)

RAR/RXR (5)

Reactive Oxygen Species (17)

Ribosomal S6 Kinase (RSK) (1)

SARS-CoV (2)

Sirtuin (7)

STAT (1)

STING (1)

TNF Receptor (2)

Topoisomerase (1)

By Research Areas:

Cancer (49)

Cardiovascular Disease (15)

Endocrinology (1)

Infection (7)

Inflammation/Immunology (39)

Metabolic Disease (14)

Neurological Disease (17)

106

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: FAP LAG-3

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-115849

Nrf2-Activator-12G	Keap1-Nrf2	Neurological Disease
Nrf2-Activator-12G (compd 12g) is an activator of *Nrf2. Nrf2-Activator-12G induces the expression of nrf2-dependentantioxidant enzymes at both mRNA and protein levels in DAergic neuronal cell. Nrf2-Activator*-12G can used in study Parkinson’s Disease .

HY-P1328

TAT-14 1 Publications Verification	Keap1-Nrf2	Others
TAT-14 is a 14-mer peptide that acts as Nrf2* activator* with an anti-inflammatory effect. TAT-14 has no effect on Nrf2 mRNA expression, but increases Nrf2 protein level due to targeting the Nrf2 binding site on Keap1 .

HY-148480

Nrf2 activator-6	Keap1-Nrf2	Cardiovascular Disease
Nrf2 activator-6, a tetrahydroisoquinoline compound, is a *Nrf2* activator. Nrf2 activator-6 has an IC₅₀ of 5 nM for inhibiting the Kelch domain-Nrf2 interaction (WO2021214470A1; Example 4) .

HY-P1328A

TAT-14 TFA	Keap1-Nrf2	Others
TAT-14 TFA is a 14-mer peptide that acts as Nrf2* activator* with an anti-inflammatory effect. TAT-14 TFA has no effect on Nrf2 mRNA expression, but increases Nrf2 protein level due to targeting the Nrf2 binding site on Keap1 .

HY-145390

Nrf2 activator-1	Keap1-Nrf2	Inflammation/Immunology
Nrf2 activator-1 is a potent activator of NF-E2 related factor 2 (Nrf2). Nrf2 activator-1 has the potential for the research of COPD and other respiratory diseases, including asthma, Acute Lung Injury (ALI), Acute Respiratory Distress Syndrome (ARDS) and pulmonary fibrosis (extracted from patent WO2018109647A1) .

HY-156081

Nrf2 activator-9	Keap1-Nrf2 Apoptosis	Metabolic Disease
Nrf2 activator-9 (compound D-36) is an Nrf2 activator that inhibits oxidized low-density lipoprotein (oxLDL) and high glucose (HG)-induced apoptosis in HUVEC cells. Nrf2 activator-9 inhibits oxLDL and HG-induced vascular endothelial cell (VEC) injury and can effectively prevent and treat atherosclerosis .

HY-163027

R079	Keap1-Nrf2	Neurological Disease Inflammation/Immunology
R079 (compound 17) is a selective, orally active *Nrf2* activator. R079 increases Nrf2 translocation activity (EC₅₀ = 32.41 μM). R079 can neutralize excess levels of reactive oxygen species through activating Nrf2. R079 has anti-inflammatory properties and can be used in multiple sclerosis research .

HY-162152

biKEAP1	Keap1-Nrf2	Inflammation/Immunology
biKEAP1 (compound 3) is an inhibitor targeting the dimerKEAP1. biKEAP1 binds to cellular KEAP1 dimers and releases the NRF2 protein sequestered by KEAP1, resulting in immediate activation of NRF2. biKEAP1 also promotes nuclear translocation of NRF2 and directly inhibits proinflammatory cytokine transcription. biKEAP1 can reduce acute inflammation and reduce inflammatory damage in acute inflammation models .

HY-145879

Nrf2 activator-2	Keap1-Nrf2	Cancer
Nrf2 activator-2 (compound O15), a Osthole derivative, is a potent *Nrf2* agonist with an EC₅₀ of 2.9 μM in 293 T cells. Nrf2 activator-2 effectively inhibits the interaction between Keap1 and Nrf2, thus showing the activation effect on Nrf2. Nrf2 activator-2 shows a marked decrease in the level of ubiquitinated Nrf2 in cells .

HY-149244

Nrf2 activator-7

Keap1-Nrf2 Others

Nrf2 activator-7 (Compound 12b) is a potent Nrf2 activator and significantly activates the Nrf2 signaling pathway.

Nrf2 activator-7	Keap1-Nrf2	Others
Nrf2 activator-7 (Compound 12b) is a potent *Nrf2* activator and significantly activates the *Nrf2* signaling pathway.

HY-143333

Nrf2 activator-3	Keap1-Nrf2	Neurological Disease Inflammation/Immunology
Nrf2 activator-3 is a potent *Nrf2* activator. Nrf2 activator-3 is used for cerebral ischemic injury research .

HY-19734

NK-252

5+ Cited Publications

Keap1-Nrf2 Cancer

NK-252 is a potential Nrf2 activator, which exhibits a great Nrf2-activating potential.

NK-252 5+ Cited Publications	Keap1-Nrf2	Cancer
NK-252 is a potential *Nrf2* activator, which exhibits a great *Nrf2*-activating potential.

HY-151430

Nrf2/HO-1 activator 1	Keap1-Nrf2 ERK Akt JNK Reactive Oxygen Species	Neurological Disease
Nrf2/HO-1 activator 1 (Compound 24) is a potent *Nrf2/HO-1* activator, neuroprotective agent. Nrf2/HO-1 activator 1 shows neuroprotective and antioxidant activities. Nrf2/HO-1 activator 1 can be used in Parkinson's disease (PD) research .

HY-122550

Artemisitene	Keap1-Nrf2 Topoisomerase Apoptosis	Cancer
Artemisitene, a natural derivative of Artemisinin, is a *Nrf2* activator with antioxidant and anticancer activities. Artemisitene activates Nrf2 by decreasing Nrf2 ubiquitination and increasing its stability .

HY-146086

Nrf2 activator-4	Keap1-Nrf2 Reactive Oxygen Species	Neurological Disease Inflammation/Immunology
Nrf2 activator-4 (Compound 20a) is a highly potent, orally active *Nrf2* activator with an EC₅₀ of 0.63 µM. Nrf2 activator-4 suppresses reactive oxygen species against oxidative stress in microglia. Nrf2 activator-4 effectively recovers the learning and memory impairment in a scopolamine-induced mouse model .

HY-151431

Nrf2/HO-1 activator 2	Keap1-Nrf2 Reactive Oxygen Species ERK Akt JNK	Neurological Disease
Nrf2/HO-1 activator 2 (compound 13m), difluoro-substituted derivative, is a potent *Nrf2/HO-1* activator. Nrf2/HO-1 activator 2 has neuroprotective and antioxidant effects through the Nrf2/HO-1 pathway mediated by phosphorylation of ERK1/2, JNK, or Akt in PC12 cells. Nrf2/HO-1 activator 2 can be used in the research of Parkinson's disease (PD) .

HY-155572

Nrf2 activator-8	Keap1-Nrf2	Inflammation/Immunology
Nrf2 activator-8 (compound 10e) is a *Nrf2* activator (EC₅₀=37.9 nM). Nrf2 activator-8 exhibits remarkable antioxidant and anti-inflammatory effects in BV-2 microglial cells. Nrf2 activator-8 can significantly restore spatial memory deficits in a mouse model of lipopolysaccharide (LPS)-induced neuroinflammation .

HY-156065

S217879	Keap1-Nrf2	Metabolic Disease
S217879 is a highly potent and selective *NRF2* activator. S217879 disrupts the KEAP1-NRF2 interaction leading to robust NRF2 pathway activation. S217879 can be used for non-alcoholic steatohepatitis (NASH) research .

HY-146168

Nrf2 activator-5	Keap1-Nrf2	Inflammation/Immunology
Nrf2 activator-5 (compound 1) is a potent *Nrf2* activator that can attenuate H₂O₂-induced oxidative stress and LPS-stimulated inflammation in BV-2 microglial cells. Nrf2 activator-5 exhibits antioxidant and anti-inflammatory activities .

HY-110258

ML334 5 Publications Verification LH601A	Keap1-Nrf2	Cancer
ML334 is a potent, cell permeable activator of *NRF2* by inhibition of *Keap1-NRF2* protein-protein interaction. ML334 binds to Keap1 Kelch domain with a K_d of 1 μM. ML334 stimulates *NRF2* expression and nuclear translocation and induces antioxidant response elements (ARE) activity .

HY-144634

DDO-7263	Keap1-Nrf2	Neurological Disease Inflammation/Immunology
DDO-7263, a 1,2,4-Oxadiazole derivative, is a potent *Nrf2-ARE* activator. DDO-7263 upregulates Nrf2 through binding to Rpn6 to block the assembly of 26S proteasome and the subsequent degradation of ubiquitinated Nrf2. DDO-7263 induces Nrf2 translocation into the nucleus. DDO-7263 inhibits of NLRP3 inflammasome activation. DDO-7263 exerts anti-inflammatory activity and has the potential for neurodegenerative diseases research, such as Parkinson's disease (PD) .

HY-121523

MIND4-17	Keap1-Nrf2	Metabolic Disease
MIND4-17 is a potent *NRF2* activator that covalently modifies a C151 residue of Keap1. MIND4-17 disrupts Keap1-Nrf2 association, leading to Nrf2 protein stabilization and nuclear translocation. MIND4‐17 exerts potent antioxidant activity .

HY-W009731

Dibenzoylmethane	Keap1-Nrf2	Metabolic Disease Cancer
Dibenzoylmethane, a minor ingredient in licorice, activates *Nrf2* and prevents various cancers and oxidative damage. Dibenzoylmethane, an analog of curcumin, results in dissociation from Keap1 and nuclear translocation of Nrf2 .

HY-100489

TBHQ 65+ Cited Publications tert-Butylhydroquinone	Keap1-Nrf2 ERK Autophagy Apoptosis Ferroptosis	Cancer
TBHQ (tert-Butylhydroquinone) is a widely used *Nrf2* activator, protects against Doxorubicin (DOX)-induced cardiotoxicity through activation of *Nrf2* . TBHQ (tert-Butylhydroquinone) is also an ERK activator; rescues Dehydrocorydaline (DHC)-induced cell proliferation inhibitionin melanoma .

HY-110275

RA839	Keap1-Nrf2	Others
RA839 is a noncovalent small molecule binder to Keap1 with a K_d of ∼6 μM and selective activator of Nrf2 signaling. RA839 prevents the induction of both inducible nitric-oxide synthase expression and nitric oxide release in response to lipopolysaccharides in macrophages. RA839 is a selective inhibitor of the Keap1/Nrf2 interaction and a useful tool compound to study the biology of Nrf2 .

HY-12213

CDDO-EA

2 Publications Verification

CDDO ethyl amide; TP319; RTA 405
Keap1-Nrf2 Cancer

CDDO-EA is an NF-E2 related factor 2/antioxidant response element (Nrf2/ARE) activator.

CDDO-EA 2 Publications Verification CDDO ethyl amide; TP319; RTA 405	Keap1-Nrf2	Cancer
CDDO-EA is an NF-E2 related factor 2/antioxidant response element (Nrf2/ARE) activator.

HY-131592

Tricetin	Apoptosis Keap1-Nrf2	Neurological Disease Inflammation/Immunology Cancer
Tricetin is a potent competitive inhibitor of the *Keap1-Nrf2* Protein Protein Interaction (PPI). Tricetin protects against 6-OHDA-induced neurotoxicity in Parkinson's disease model by activating Nrf2/HO-1 signaling pathway and preventing mitochondria-dependent apoptosis pathway .

HY-110258B

(R,S,R)-ML334 (R,S,R)-LH601A	Others	Cancer
(R,S,R)-ML334 is the isomer of ML334 (HY-110258), and can be used as an experimental control. ML334 is a potent, cell permeable activator of *NRF2* by inhibition of *Keap1-NRF2* protein-protein interaction. ML334 binds to Keap1 Kelch domain with a K_d of 1 μM. ML334 stimulates *NRF2* expression and nuclear translocation and induces antioxidant response elements (ARE) activity .

HY-W505984

TPNA10168 KM05073	Keap1-Nrf2	Inflammation/Immunology
TPNA10168 is an *Nrf-2* activator that activates the *Keap1-Nrf2-ARE* pathway. TPNA10168 is neuroprotective against oxidative stress-induced damage. TPNA10168 significantly reduces the transcription of inflammatory genes, including TNF-α, IL-1β, IL-6, and iNOS. TPNA10168 can be used in research on anti-inflammatory and neurological diseases .

HY-101371

Hesperin

Keap1-Nrf2 Cancer

Hesperin is a bioactive ingredient present in Japanese horseradish (wasabi) and has been shown to be an Nrf2 activator.

Hesperin	Keap1-Nrf2	Cancer
Hesperin is a bioactive ingredient present in Japanese horseradish (wasabi) and has been shown to be an *Nrf2* activator.

HY-N0509

Astilbin 2 Publications Verification	Keap1-Nrf2 TNF Receptor NF-κB	Inflammation/Immunology Cancer
Astilbin is a flavonoid compound and enhances *NRF2* activation. Astilbin also suppresses TNF-α expression and NF-κB activation.

HY-100489R

TBHQ (Standard) tert-Butylhydroquinone (Standard)	Keap1-Nrf2 ERK Autophagy Apoptosis Ferroptosis	Cancer
TBHQ (Standard) is the analytical standard of TBHQ. This product is intended for research and analytical applications. TBHQ (tert-Butylhydroquinone) is a widely used *Nrf2* activator, protects against Doxorubicin (DOX)-induced cardiotoxicity through activation of *Nrf2* . TBHQ (tert-Butylhydroquinone) is also an ERK activator; rescues Dehydrocorydaline (DHC)-induced cell proliferation inhibitionin melanoma .

HY-134205A

CBR-470-1 1 Publications Verification	Keap1-Nrf2	Neurological Disease Metabolic Disease
CBR-470-1 is an inhibitor of the glycolytic enzyme phosphoglycerate kinase 1 (PGK1). CBR-470-1 is also a non-covalent *Nrf2* activator. CBR-470-1 protects SH-SY5Y neuronal cells against MPP ⁺-induced cytotoxicity through activation of the Keap1-Nrf2 cascade .

HY-N12486

Isofalcarintriol	Keap1-Nrf2 ATP Synthase	Metabolic Disease
Isofalcarintriol is a *NRF2* activator and selective inhibitor of the mitochondrial ATP synthase. Isofalcarintriol can be used for aging study .

HY-N0643

Carnosol 5+ Cited Publications	Ribosomal S6 Kinase (RSK) Keap1-Nrf2 Endogenous Metabolite	Cancer
Carnosol is a potent Ribosomal S6 Kinase (RSK2) inhibitor that could be useful for treating gastric cancer, with an IC₅₀ of ~5.5 μM . Carnosol, a *Nrf2* activator, increases the nuclear levels of Nrf2 and can promote the expression of heme oxygenase 1 (HMOX1) .

HY-14645A

(+)-DHMEQ 2 Publications Verification (1R,2R,6R)-Dehydroxymethylepoxyquinomicin; (1R,2R,6R)-DHMEQ	Keap1-Nrf2	Inflammation/Immunology
(+)-DHMEQ is an activator of antioxidant transcription factor *Nrf2*. (+)-DHMEQ is the enantiomer of (-)-DHMEQ. (-)-DHMEQ inhibits NF-kB than its enantiomer (+)-DHMEQ.

HY-N1244

Sarmentosin Sarmentosine; Sarmentosine (glycoside)	Keap1-Nrf2 mTOR Apoptosis	Cancer
Sarmentosin is an activator of *Nrf2. Sarmentosin inhibits mTOR* signaling and induces autophagy-dependent apoptosis in human HCC cells .

HY-15725

CDDO-Im 5+ Cited Publications RTA-403; TP-235; CDDO-Imidazolide	Keap1-Nrf2 PPAR Ferroptosis	Cancer
CDDO-Im (RTA-403) is an activator of *Nrf2* and PPAR, with K_is of 232 and 344 nM for PPARα and PPARγ .

HY-14909

Bardoxolone 10+ Cited Publications CDDO; RTA 401	Keap1-Nrf2 Necroptosis	Metabolic Disease
Bardoxolone (CDDO) is a novel nuclear regulatory factor (Nrf-2) activator for the study of chronic kidney disease. Bardoxolone is a potent necroptosis inhibitor that inhibits Z-VAD-FMK-induced necroptosis .

HY-N3260

Methyllucidone	Reactive Oxygen Species Keap1-Nrf2 PI3K	Inflammation/Immunology
Methyllucidone is a neuroprotective agent and an antioxidant that can be isolated from Lindera erythrocarpa Makino. Methyllucidone inhibits the ROS production, and activates antioxidant signaling pathways that include *Nrf-2* and PI3K .

HY-N0892

AKBA 1 Publications Verification Acetyl-11-keto-β-boswellic acid	HIF/HIF Prolyl-Hydroxylase Reactive Oxygen Species Endogenous Metabolite	Cancer
AKBA (Acetyl-11-keto-β-boswellic acid) is an active triterpenoid compound from the extract of Boswellia serrate and a novel Nrf2 activator.

HY-N0606

Ginsenoside Rh3 1 Publications Verification	Keap1-Nrf2	Inflammation/Immunology
Ginsenoside Rh3 is a bacterial metabolite of Ginsenoside Rg5. Ginsenoside Rh3 treatment in human retinal cells induces *Nrf2* activation.

HY-112675

4-Octyl itaconate 40+ Cited Publications	Keap1-Nrf2	Inflammation/Immunology
4-Octyl Itaconate is a cell-permeable Itaconate derivative. Itaconate is an anti-inflammatory metabolite that activates *Nrf2* via alkylation of KEAP1 .

HY-N0826

Corynoline 2 Publications Verification	Cholinesterase (ChE) Keap1-Nrf2	Neurological Disease Inflammation/Immunology Cancer
Corynoline is a reversible and noncompetitive acetylcholinesterase (AChE) inhibitor with an IC₅₀ of 30.6 μM . Corynoline exhibits anti-inflammatory activity by activating *Nrf2* .

HY-112671

CDDO-dhTFEA RTA dh404	Keap1-Nrf2 NF-κB	Inflammation/Immunology
CDDO-dhTFEA (RTA dh404) is a synthetic oleanane triterpenoid compound which potently activates *Nrf2* and inhibits the pro-inflammatory transcription factor NF-κB . CDDO-dhTFEA restores hypertension (MAP), increases Nrf2 and expression of its target genes, attenuates activation of NF-κB and transforming growth factor-β pathways, and reduces glomerulosclerosis, interstitial fibrosis and inflammation in the chronic kidney disease (CKD) rats .

HY-134001

CBR-470-2

Keap1-Nrf2 Metabolic Disease

CBR-470-2, a glycine-substituted analog, can activate NRF2 signaling. CBR-470-2 can be used for the research of modulation glycolysis .

CBR-470-2	Keap1-Nrf2	Metabolic Disease
CBR-470-2, a glycine-substituted analog, can activate *NRF2* signaling. CBR-470-2 can be used for the research of modulation glycolysis .

HY-12212

Omaveloxolone 15+ Cited Publications RTA 408	Keap1-Nrf2 STING Apoptosis	Inflammation/Immunology Cancer
Omaveloxolone (RTA 408) is an antioxidant inflammation modulator (AIM), which activates *Nrf2* and suppresses nitric oxide (NO). Omaveloxolone attenuates osteoclastogenesis by inhibiting STING dependent NF-κb signaling.

HY-13755

Sulforaphane 30+ Cited Publications	HDAC Keap1-Nrf2 Apoptosis Bcl-2 Family Caspase Reactive Oxygen Species	Inflammation/Immunology Cancer
Sulforaphane is an orally active inducer of the *Keap1/Nrf2/ARE* pathway. Sulforaphane promotes the transcription of tumor-suppressing proteins and effectively inhibits the activity of HDACs. Through the activation of the Keap1/Nrf2/ARE pathway and further induction of HO-1 expression, Sulforaphane protects the heart. Sulforaphane suppresses high glucose-induced pancreatic cancer through AMPK-dependent signal transmission. Sulforaphane exhibits both anticancer and anti-inflammatory properties .

HY-13324

Bardoxolone methyl 20+ Cited Publications RTA 402; NSC 713200; CDDO Methyl ester	Keap1-Nrf2 Autophagy Apoptosis Ferroptosis	Cancer
Bardoxolone methyl (NSC 713200; RTA 402; CDDO Methyl ester) is a synthetic triterpenoid compound with potential antineoplastic and anti-inflammatory activities, acting as an activator of the *Nrf2* pathway and an inhibitor of the NF-κB pathway.

HY-17376

Ezetimibe 5+ Cited Publications SCH 58235	Keap1-Nrf2 Autophagy	Cardiovascular Disease Cancer
Ezetimibe (SCH 58235) is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent *Nrf2* activator.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-122550

Artemisitene	Piscidia erythrina L. Terpenoids Sesquiterpenes Source classification Plants Compositae	Keap1-Nrf2 Topoisomerase Apoptosis
Artemisitene, a natural derivative of Artemisinin, is a *Nrf2* activator with antioxidant and anticancer activities. Artemisitene activates Nrf2 by decreasing Nrf2 ubiquitination and increasing its stability .

HY-W009731

Dibenzoylmethane	Classification of Application Fields Leguminosae Ketones, Aldehydes, Acids Source classification Metabolic Disease Plants Disease Research Fields Glycyrrhiza uralensis Fisch.	Keap1-Nrf2
Dibenzoylmethane, a minor ingredient in licorice, activates *Nrf2* and prevents various cancers and oxidative damage. Dibenzoylmethane, an analog of curcumin, results in dissociation from Keap1 and nuclear translocation of Nrf2 .

HY-131592

Tricetin	Flavonols Flavonoids Cupressaceae Classification of Application Fields Neurological Disease Thuja occidentalisLinn. Source classification Plants Disease Research Fields Inflammation/Immunology	Apoptosis Keap1-Nrf2
Tricetin is a potent competitive inhibitor of the *Keap1-Nrf2* Protein Protein Interaction (PPI). Tricetin protects against 6-OHDA-induced neurotoxicity in Parkinson's disease model by activating Nrf2/HO-1 signaling pathway and preventing mitochondria-dependent apoptosis pathway .

HY-N0509

Astilbin 2 Publications Verification	Flavanonols Structural Classification Flavonoids other families Microorganisms Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields Cancer	Keap1-Nrf2 TNF Receptor NF-κB
Astilbin is a flavonoid compound and enhances *NRF2* activation. Astilbin also suppresses TNF-α expression and NF-κB activation.

HY-N12486

Isofalcarintriol	Structural Classification Natural Products Source classification Decachaeta ovatifolia (DC.) R.M.King & H.Rob. Plants Umbelliferae	Keap1-Nrf2 ATP Synthase
Isofalcarintriol is a *NRF2* activator and selective inhibitor of the mitochondrial ATP synthase. Isofalcarintriol can be used for aging study .

HY-N0643

Carnosol 5+ Cited Publications	Structural Classification Classification of Application Fields Brachyclados megalanthus Speg. Food Preservation Research Source classification Plants Agricultural Research Terpenoids Labiatae Phenols Polyphenols Diterpenoids Disease Research Fields Cancer	Ribosomal S6 Kinase (RSK) Keap1-Nrf2 Endogenous Metabolite
Carnosol is a potent Ribosomal S6 Kinase (RSK2) inhibitor that could be useful for treating gastric cancer, with an IC₅₀ of ~5.5 μM . Carnosol, a *Nrf2* activator, increases the nuclear levels of Nrf2 and can promote the expression of heme oxygenase 1 (HMOX1) .

HY-N1244

Sarmentosin Sarmentosine; Sarmentosine (glycoside)	Structural Classification Natural Products Animals Source classification Saccharides Monosaccharides	Keap1-Nrf2 mTOR Apoptosis
Sarmentosin is an activator of *Nrf2. Sarmentosin inhibits mTOR* signaling and induces autophagy-dependent apoptosis in human HCC cells .

HY-N3260

Methyllucidone	Structural Classification Natural Products Source classification Plants Lauraceae	Reactive Oxygen Species Keap1-Nrf2 PI3K
Methyllucidone is a neuroprotective agent and an antioxidant that can be isolated from Lindera erythrocarpa Makino. Methyllucidone inhibits the ROS production, and activates antioxidant signaling pathways that include *Nrf-2* and PI3K .

HY-N0892

AKBA 1 Publications Verification Acetyl-11-keto-β-boswellic acid	Triterpenes Structural Classification Classification of Application Fields Terpenoids Boswellia serrata Plants Burseraceae Disease Research Fields Cancer	HIF/HIF Prolyl-Hydroxylase Reactive Oxygen Species Endogenous Metabolite
AKBA (Acetyl-11-keto-β-boswellic acid) is an active triterpenoid compound from the extract of Boswellia serrate and a novel Nrf2 activator.

HY-N0606

Ginsenoside Rh3 1 Publications Verification	Panax ginseng C. A. Meyer Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Plants Inflammation/Immunology Disease Research Fields Araliaceae	Keap1-Nrf2
Ginsenoside Rh3 is a bacterial metabolite of Ginsenoside Rg5. Ginsenoside Rh3 treatment in human retinal cells induces *Nrf2* activation.

HY-N0826

Corynoline 2 Publications Verification	Alkaloids other families Classification of Application Fields Neurological Disease Source classification Plants Isoquinoline Alkaloids Disease Research Fields Cancer	Cholinesterase (ChE) Keap1-Nrf2
Corynoline is a reversible and noncompetitive acetylcholinesterase (AChE) inhibitor with an IC₅₀ of 30.6 μM . Corynoline exhibits anti-inflammatory activity by activating *Nrf2* .

HY-13755

Sulforaphane 30+ Cited Publications	Structural Classification Natural Products other families Classification of Application Fields Source classification Plants Inflammation/Immunology Disease Research Fields	HDAC Keap1-Nrf2 Apoptosis Bcl-2 Family Caspase Reactive Oxygen Species
Sulforaphane is an orally active inducer of the *Keap1/Nrf2/ARE* pathway. Sulforaphane promotes the transcription of tumor-suppressing proteins and effectively inhibits the activity of HDACs. Through the activation of the Keap1/Nrf2/ARE pathway and further induction of HO-1 expression, Sulforaphane protects the heart. Sulforaphane suppresses high glucose-induced pancreatic cancer through AMPK-dependent signal transmission. Sulforaphane exhibits both anticancer and anti-inflammatory properties .

HY-N11682

Microcystin-LY	Structural Classification Animals Ketones, Aldehydes, Acids Source classification	Keap1-Nrf2
Microcystin-LY, a cyclic heptapeptide toxin from the cyanobacterium Microcystis aeruginosa , acts as an activator of the *Nrf2* pathway to induce oxidative stress response, and the induction effect is most obvious at 3μM. .

HY-N12344

n-Butyl α-D-fructofuranoside	Structural Classification Natural Products other families Source classification Ulmus davidiana var. japonica (Rehd.)Nakai Plants	JNK
n-Butyl α-D-fructofuranoside, isolated from the root barks of Ulmus davidiana var. japonica, enhances Nrf2 activity through activation of JNK and has antiinflammation activity .

HY-N0290

Mangiferin 5+ Cited Publications	Structural Classification Liliaceae Xanthones Classification of Application Fields Source classification Phenols Polyphenols Anemarrhena asphodeloides Bunge Plants Disease Research Fields Cancer	NF-κB Keap1-Nrf2 Apoptosis
Mangiferin is a *Nrf2* activator. Mangiferin suppresses nuclear translocation of the NF-κB subunits p65 and p50. Mangiferin exhibits antioxidant, antidiabetic, antihyperuricemic, antiviral, anticancer and antiinflammatory activities .

HY-124941

7-Deacetylgedunin	Structural Classification Natural Products Toona sinensis (A. Juss.) Roem. Source classification Plants Meliaceae	Keap1-Nrf2 Reactive Oxygen Species
7-Deacetylgedunin is an activator of *Keap1/Nrf2/HO-1. 7-Deacetylgedunin alleviates mice mortality induced by LPS. 7-Deacetylgedunin inhibits Keap1* expression and suppresses macrophage proliferation. 7-Deacetylgedunin suppresses inflammation in vivo and in vitro .

HY-N10431

Stigmane B	Zea mays L. Terpenoids Gramineae Source classification Diterpenoids Plants	Keap1-Nrf2
Stigmane B (Compound 2) is a nuclear factor E2-related factor (Nrf2) activator. Stigmane B downregulates apoptosis and reactive oxygen species (ROS) generation, and increases antioxidant enzyme activities. Stigmane B shows neuroprotective effects .

HY-N0106

(Rac)-Salvianic acid A sodium (Rac)-Danshensu sodium; (Rac)-Tanshinol sodium	Structural Classification Classification of Application Fields Simple Phenylpropanols Labiatae Source classification Samanea saman (Jacq.) Merr. Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields Cancer	Others
(Rac)-Salvianic acid A sodium is the racemate of Salvianic acid A (HY-N1913). Salvianic acid A, an orally active phenolic compound, can induce Nrf2/HO-1 activation and inhibition of NF-κB pathway. Danshensu has anti-oxidation, anti-apoptosis, anti-lung inflammatory and has the potential for COVID-19, cardiovascular and cerebrovascular diseases research .

HY-113145

(Rac)-Salvianic acid A (Rac)-Danshensu; (Rac)-Tanshinol	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Labiatae Source classification Samanea saman (Jacq.) Merr. Other Diseases Phenols Polyphenols Plants Disease Research Fields	Others
(Rac)-Salvianic acid A is the racemate of Salvianic acid A (HY-N1913). Salvianic acid A, an orally active phenolic compound, can induce Nrf2/HO-1 activation and inhibition of NF-κB pathway. Danshensu has anti-oxidation, anti-apoptosis, anti-lung inflammatory and has the potential for COVID-19, cardiovascular and cerebrovascular diseases research .

HY-N10405

(R)-5-Hydroxy-1,7-diphenyl-3-heptanone	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Alpinia officinarum Hance Plants Disease Research Fields Zingiberaceae	Keap1-Nrf2
(R)-5-Hydroxy-1,7-diphenyl-3-heptanone is a diarylheptanoid that can be found in Alpinia officinarum. (R)-5-Hydroxy-1,7-diphenyl-3-heptanone ameliorates oxidative stress and insulin resistance via activation of Nrf2/ARE pathway .

HY-17363

Dimethyl fumarate 20+ Cited Publications	Infection Structural Classification Natural Products Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Keap1-Nrf2 Reactive Oxygen Species HIV Autophagy Endogenous Metabolite
Dimethyl fumarate (DMF) is an orally active and brain-penetrant *Nrf2* activator and induces upregulation of antioxidant gene expression. Dimethyl fumarate induces necroptosis in colon cancer cells through GSH depletion/ROS increase/MAPKs activation pathway, and also induces cell autophagy. Dimethyl fumarate can be used for multiple sclerosis research .

HY-N3847

Eriodictyol-7-O-glucoside Eriodictyol 7-O-β-D-glucoside	Flavonoids Classification of Application Fields Labiatae Flavonones Source classification Phenols Polyphenols Metabolic Disease Solidago altissima Linnaeus Plants Disease Research Fields	Keap1-Nrf2
Eriodictyol-7-O-glucoside (Eriodictyol 7-O-β-D-glucoside), a flavonoid, is a potent free radical scavenger. Eriodictyol-7-O-glucoside is also an *Nrf2* activator, confers protection against Cisplatin-induced toxicity .

HY-120912

Gingerenone A	Zingiber officinale Roscoe Structural Classification Source classification Phenols Polyphenols Plants Zingiberaceae	Keap1-Nrf2 Glutathione Peroxidase
Gingerenone A is a *Nrf2-Gpx4* activator with anti-breast-cancer properties. Gingerenone A results a delayed G2/M in cancer cells, following oxidative stress and senescence responses. Gingerenone A also alleviates ferroptosis in secondary liver injury (SLI) in dextran sodium sulfate (DSS)-induced colitis mice. Gingerenone A can be isolated from Zingiber officinale .

HY-122936

Tanshindiol C	Structural Classification Terpenoids Labiatae Samanea saman (Jacq.) Merr. Diterpenoids Plants	Histone Methyltransferase Keap1-Nrf2 Sirtuin
Tanshindiol C is a S-adenosylmethionine-competitive EZH2 (Histone Methyltransferase) inhibitor with an IC₅₀ of 0.55 μM for inhibiting the methyltransferase activity. Tanshindiol C is also an activator of both *Nrf2* and Sirtuin 1 (Sirt1) in macrophages. Tanshindiol C possesses anti-cancer activity, and can be used for atherosclerosis research .

HY-14649

Retinoic acid 45+ Cited Publications Vitamin A acid; all-trans-Retinoic acid; ATRA	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Whitening Agent Cosmetic Research Endogenous metabolite Disease Research Fields Cancer	Organoid RAR/RXR PPAR Endogenous Metabolite Autophagy
Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC₅₀s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with K_d of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha.

HY-N8160

Dehydrocurdione	Classification of Application Fields Terpenoids Sesquiterpenes Source classification Plants Curcuma phaeocaulis Valeton Disease Research Fields Inflammation/Immunology Zingiberaceae	Keap1-Nrf2 Reactive Oxygen Species
Dehydrocurdione, a zedoary-derived sesquiterpene, induces heme oxygenase (HO)-1, an antioxidative enzyme, in RAW 264.7 macrophages. Dehydrocurdione interacts with Keap1, resulting in Nrf2 translocation followed by activation of the HO-1 E2 enhancer. Dehydrocurdione suppresses lipopolysaccharide-induced NO release, a marker of inflammation. Anti-inflammatory activity .

HY-N0028

Forsythiaside A 1 Publications Verification	Structural Classification Classification of Application Fields Oleaceae Simple Phenylpropanols Source classification Phenols Polyphenols Phenylpropanoids Plants Forsythia suspensa (Thunb.) Vahl Inflammation/Immunology Disease Research Fields	Others
Forsythiaside A is an orally active phenylethanoid glycoside isolated from the dried fruits of Forsythia suspensa. Forsythiaside A is also an inhibitor of COX-2 and has anti-inflammatory, antioxidant and neuroprotective effects. Forsythiaside A prevents neuroinflammation and apoptosis caused by Aβ_25-35 damage and may be used in Alzheimer's disease (AD) research. Forsythiaside A also activates the Nrf2/HO-1 signaling pathway and inhibits OVA-induced asthma in mice .

HY-N6953

Garcinone D 2 Publications Verification	Xanthones Source classification Guttiferae Phenols Polyphenols Garcinia mangostana Linn. Plants	STAT Keap1-Nrf2 Reactive Oxygen Species
Garcinone D, a natural xanthone from mangosteen, promotes the proliferation of C17.2 neural stem cell. Garcinone D increases the protein levels of *phosphorylated signal transducer and activator* of transcription 3 (p-STAT3)*, Cyclin D1 and nuclear factor erythroid 2-related factor (Nrf2), heme oxygenase-1 (HO-1)* in concentration- and time- dependent manners .

HY-14649R

Retinoic acid (Standard) 45+ Cited Publications Vitamin A acid (Standard); all-trans-Retinoic acid (Standard); ATRA (Standard)	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Cancer	RAR/RXR PPAR Endogenous Metabolite Autophagy
Retinoic acid (Standard) is the analytical standard of Retinoic acid. This product is intended for research and analytical applications. Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC₅₀s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with K_d of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha.

HY-N1913

Danshensu 1 Publications Verification Dan shen suan A; Salvianic acid A	Structural Classification Classification of Application Fields Simple Phenylpropanols Labiatae Samanea saman (Jacq.) Merr. Source classification Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields Cancer	Keap1-Nrf2 NF-κB Reactive Oxygen Species SARS-CoV Apoptosis
Danshensu (Dan shen suan A), an orally active phenolic compound, can induce *Nrf2/HO-1* activation and inhibition of NF-κB pathway. Danshensu reduces reactive oxygen species (ROS) production, upregulates antioxidant defense mechanism and inhibits intrinsic apoptotic pathway. Danshensu displays a potent antiviral activity against SARS-CoV-2 with EC₅₀ of 0.97 μM. Danshensu has anti-oxidation, anti-apoptosis, anti-lung inflammatory and has the potential for COVID-19, cardiovascular and cerebrovascular diseases research .

HY-N1913A

Danshensu sodium Dan shen suan A sodium; Salvianic acid A sodium	Structural Classification Simple Phenylpropanols Labiatae Source classification Samanea saman (Jacq.) Merr. Phenols Polyphenols Phenylpropanoids Plants	Keap1-Nrf2 NF-κB Reactive Oxygen Species SARS-CoV Apoptosis
Danshensu (Dan shen suan A) sodium, an orally active phenolic compound, can induce *Nrf2/HO-1* activation and inhibition of NF-κB pathway. Danshensu sodium reduces reactive oxygen species (ROS) production, upregulates antioxidant defense mechanism and inhibits intrinsic apoptotic pathway. Danshensu sodium displays a potent antiviral activity against SARS-CoV-2 with EC₅₀ of 0.97 μM. Danshensu sodium has anti-oxidation, anti-apoptosis, anti-lung inflammatory and has the potential for COVID-19, cardiovascular and cerebrovascular diseases research .

HY-16561

Resveratrol Maximum Cited Publications 77 Publications Verification trans-Resveratrol; SRT501	Structural Classification Classification of Application Fields Anti-aging Source classification Vitis vinifera cv. Zalema Plants Vitaceae Infection Microorganisms Functional Molecules Sunscreen Research of Health Products Phenols Polyphenols Cosmetic Research Inflammation/Immunology Disease Research Fields Cancer	IKK Autophagy Mitophagy Sirtuin Apoptosis Bacterial Fungal Antibiotic Keap1-Nrf2
Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator . Resveratrol is a potent pregnane X receptor (PXR) inhibitor . Resveratrol is an *Nrf2* activator, ameliorates aging-related progressive renal injury in mice model . Resveratrol increases production of NO in endothelial cells .

HY-N0568

Madecassoside Asiaticoside A	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Other Diseases Plants Umbelliferae Vitex trifolia L. Endogenous metabolite Disease Research Fields	Endogenous Metabolite Apoptosis Autophagy Keap1-Nrf2 p38 MAPK Caspase
Madecassoside is a pentacyclic triterpene isolated from Centella asiatica and has anti-inflammatory properties. Antioxidant and anti-aging effects. Madecassoside is a pentacyclic triterpene isolated from Centella asiatica. Madecassoside is orally active and has inhibitory properties against inflammation, oxidation, apoptosis and autophagy. Madecassosid inhibits activities of p38 MAPK and NF-kB ^[5][6], exhibits an anti-apopototic property, activates Nrf2 expression to reduce the neurotoxicity . Madecassoside can be used in endocrine diseases, cardiovascular diseases, skin diseases and other diseases.

HY-16561R

Resveratrol (Standard) Maximum Cited Publications 77 Publications Verification trans-Resveratrol (Standard); SRT501 (Standard)	Infection Functional Molecules Classification of Application Fields Sunscreen Anti-aging Source classification Research of Health Products Cosmetic Research Plants Inflammation/Immunology Disease Research Fields Cancer	IKK Autophagy Mitophagy Sirtuin Apoptosis Bacterial Fungal Antibiotic Keap1-Nrf2
Resveratrol (Standard) is the analytical standard of Resveratrol. This product is intended for research and analytical applications. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator . Resveratrol is a potent pregnane X receptor (PXR) inhibitor . Resveratrol is an *Nrf2* activator, ameliorates aging-related progressive renal injury in mice model . Resveratrol increases production of NO in endothelial cells .

Cat. No.	Product Name	Chemical Structure

HY-17376S

Ezetimibe-d4

Ezetimibe-d₄ is the deuterium labeled Ezetimibe. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.

HY-17363S

Dimethyl fumarate-d6
Dimethyl fumarate-d₆ is a deuterium labeled Dimethyl fumarate. Dimethyl fumarate is a nuclear factor (erythroid-derived)-like 2 (Nrf2) pathway activator and induces upregulation of antioxidant gene expression[1][2][3][4][5][6].

HY-17376S1

Ezetimibe-d4-1
Ezetimibe-d₄-1 is deuterium labeled Ezetimibe. Ezetimibe (SCH 58235) is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.

HY-112675S

4-Octyl itaconate-13C5-1

4-Octyl itaconate- ¹³C₅-1 is ¹³C-labeled 4-Octyl itaconate (HY-112675). Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.

HY-12519S

Oltipraz-d3
Oltipraz-d₃ is the deuterium labeled Oltipraz. Oltipraz has an inhibitory effect on HIF-1α activation in a time-dependent manner, completely abrogating HIF-1α induction at ≥10 μM concentrations, the IC50 of Oltipraz for HIF-1α inhibition is 10 μM. Oltipraz is a potent Nrf2 activator.

HY-17363S1

Dimethyl fumarate-d2

Dimethyl fumarate-d₂ is the deuterium labeled Dimethyl fumarate[1]. Dimethyl fumarate (DMF) is an orally active and brain-penetrant Nrf2 activator and induces upregulation of antioxidant gene expression. Dimethyl fumarate induces necroptosis in colon cancer cells through GSH depletion/ROS increase/MAPKs activation pathway, and also induces cell autophagy. Dimethyl fumarate can be used for multiple sclerosis research[2][3].

HY-14649S2

11-cis-Retinoic Acid-d5

11-cis-Retinoic Acid-d₅ is the deuterium labeled Retinoic acid. Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha[1][2].

HY-14649S4

Retinoic acid-d5

Retinoic acid-d₅ is the the deuterium labeled Retinoic acid (HY-14649). Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC₅₀s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with K_d of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha .

HY-14649S3

Retinoic acid-d6

Retinoic acid-d₆ is the deuterium labeled Retinoic acid[1]. Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha[2][3][4][5][6][7].

HY-16561S1

Resveratrol-13C6

Resveratrol- ¹³C₆ is the ¹³C-labeled Resveratrol. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator[1][2][3][4]. Resveratrol is a potent pregnane X receptor (PXR) inhibitor[5]. Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model[6]. Resveratrol increases production of NO in endothelial cells[7].

HY-16561S

Resveratrol-d4

Resveratrol-d₄ is the deuterium labeled Resveratrol. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator[1][2][3][4]. Resveratrol is a potent pregnane X receptor (PXR) inhibitor[5]. Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model[6]. Resveratrol increases production of NO in endothelial cells[7].

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